Sentence examples for expression of certain microRNAs from inspiring English sources
For instance, the expression of certain microRNAs is potentially controlled by DNA methylation or histone modification.
Recent studies have shown that synovial tissue and synovial fibroblasts from patients with rheumatoid arthritis exhibit increased expression of certain microRNAs.
In mice and human cell lines, Myc abundance has been shown to be associated with changes in expression patterns of certain microRNAs, which in turn regulate the expression of other genes (Chang et al., 2008; Lin et al., 2009).
Pan and colleagues [ 78] demonstrated a connection between aberrant regulation of certain microRNAs and reduced expression of DNMT1.
Building on earlier work linking microRNAs to cancer, researchers have found that a lack of certain microRNAs encourages tumors to spread.
A correlation analysis showed that the number of regulating microRNAs or the presence of certain microRNAs does not correlate with the numbers of promoter and cis elements (data not shown), thus apparently providing independent regulatory mechanisms, regulating different aspects of gene expression.
Recent data showed that overexpression or lack of expression of certain specific microRNAs were correlated to metastatic and aggressive clinical phenotypes [ 10- 12].
More recently, it has been suggested that high red meat consumption can increase the expression of certain oncogenic microRNA.
MicroRNAs are small RNA molecules that regulate the expression of certain genes through interaction with mRNA targets and are mainly involved in human cancer.
A decrease in certain microRNAs as a result of mutations, deletions or epigenetic silencing may inhibit the expression of suppressor genes indirectly, for example, via ensuing activation of DNA methyltransferase genes.
Overexpression or inappropriate expression of authentic microRNAs may facilitate the study of their normal functions and expression of artificial microRNAs may permit effective, regulated RNA interference in vivo.
