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Sex and age are known to influence the clinical expression of asthma and allergic diseases.
Respiratory events occurring during the first years of life, even when transient, may influence the expression of asthma and lung function during childhood and early adulthood [2].
Indeed, different gene networks were associated with asthma in children with European ancestry versus African Americans suggesting that there may be distinct mechanisms underlying the pathogenesis and expression of asthma in these 2 subgroups.
However, no effect on the expression of asthma later in childhood has been observed.
Small airways dysfunction (SAD) contributes to the clinical expression of asthma.
Genetic polymorphism associated with airway hyperresponsiveness also has an impact on the expression of asthma symptoms [ 18, 47].
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However, the mechanisms by which obesity enhances the clinical expression of asthma-related physiological changes have not been fully elucidated.
While our study is among the largest gene expression studies of asthma and allergy to date it is important to note that sample size may still be an important limitation of our analyses.
Significant progress has been made in identifying genes that convey risk of development and expression of the asthma phenotype.
High total serum IgE levels are closely correlated with the clinical expression and severity of asthma and allergy [3], [4].
Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma.
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