Previous studies have shown that fasting induces changes in glucose and lipid metabolism and gene expression of appetite regulatory peptides in the mammalian hypothalamus3,4,5,6.
The homeostatic alterations induced by food deprivation can change the expression of appetite regulatory peptides within the neuroendocrine system [25].
Nutritional changes over this period modify the expression of appetite regulators and in offspring from obesity-prone rats, the hypothalamic neuron projections were shown to be permanently disrupted [16].
Yi J., Yuan J., Gilbert E. R., Siegel P. B., Cline M. A. Differential expression of appetite-regulating genes in avian models of anorexia and obesity.
Further studies are needed to determine which factors (e.g. anti-nutritional factors, palatability and nutritional deficits) contribute to reduced feed intake and growth, as well as the maximum CM inclusion level that does not negatively influence feed intake, growth rate and the transcript expression of appetite-related factors in Atlantic cod.
These results suggest that there are differences in gene expression of appetite-associated factors between LWS and HWS lines that might be associated with their differential food intake and thus contribute to differences in severity of anorexia, body weight, adiposity, and development of obesity.
To investigate the phenotype of cells resulting from the differentiation of hypothalamic neurospheres, we evaluated the expression of appetite-related neuropeptides NPY, AGRP, POMC, CART and Orexin-A.
However, the finding of attenuated induction of Npy and Agrp mRNAs in the hypothalami of fasted CXCL14−/− mice supports the idea that CXCL14 modulates the expression of appetite-regulators.
His excesses, on and off the field, seemed really just the largest expression of his appetite for life.
Tritos NA, Elmquist JK, Mastaitis JW, Flier JS, Maratos-Flier E. Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice.
