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These data indicate that ischemia elicits expression of an array of functional gene clusters that may be used as an index for stress severity and a template for target therapy design.
Originally defined on the functional basis of their "natural" ability to lyse tumor targets and thought to be a relatively homogeneous group of lymphocytes, NK cells possess a remarkable degree of phenotypic and functional diversity due to the combinatorial expression of an array of activating and inhibitory receptors.
PGC-1beta, like PGC-1alpha, potently induces the expression of an array of mitochondrial genes involved in oxidative metabolism.
Apoptosis is a well-controlled process, which involves changes in the expression of an array of genes [12].
TFEB, a member of the MiTF/TFE (microphthalmia-associated transcription factor) family of transcription factors that includes MITF, TFE3 (transcription factor binding to IGHM enhancer 3), TFEB and TFEC, controls the expression of an array of genes involved in lysosome biogenesis and autophagy (Settembre et al., 2013b; Raben and Puertollano, 2016).
Lowering of iron concentration triggers the expression of an array of virulence determinants that help the pathogen to establish a successful infection [6], [7].
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Furthermore, NaHS root pretreatment resulted in induction of gene expression levels of an array of protective molecules, such as enzymatic antioxidants (cAPX, CAT, MnSOD, GR), heat shock proteins (HSP70, HSP80, HSP90) and aquaporins (PIP).
Total RNA was extracted for qRT-PCR analysis to monitor the relative expression levels of an array of genes, including PIN1, PIN3, CYP83B1, CYP79B2 and AT4G27260 (an IAA-amido synthase).
Thus, the challenge that represents the diabetic wound healing failure is the clinical gross expression of an outstanding array of biochemical and cellular disorders [ 7].
The local signalling as a consequence to these inflammatory molecules results in the expression of an vast array of protease and consequent degradation of extracellular matrix (ECM) of the articular cartilage and the adjacent bone [ 1, 2].
Activation of these pathways leads to the expression of a large array of interferon-induced genes, leading to robust antitumour immune responses49,50.
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