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This often results in the expression of altered oncogenes or the loss of tumor suppressors, contributing to the initiation of cancer [5], [6].
Thus, the CIN phenomenon promotes the expression of altered oncogenes, the loss of tumor suppressor genes and the deletion of several other genes, such as those encoding microRNAs.
[ 1- 3] Malignant transformation is associated with abnormal glycosylation, resulting in expression of altered carbohydrate determinants, such as the Sialyl Lewis x (sLex) antigen.
Malignant transformation of tumour cells is associated with abnormal glycosylation, resulting in expression of altered carbohydrate determinants including the expression of sLex and sLea antigens [ 4, 9, 12].
Intriguingly, it should be considered that even in patients with Cushing's syndrome there are differences in the expression of altered gonadal function according to sex.
Here, we show that in PD, the expression of altered frequency-specific coupling in cortico-cortical pathways is state dependent and can be modulated by dopamine replacement.
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Moreover, the sex of the animal also appears to play some role in the nature of the expression of the altered HR-OR.
Neither the dyes nor cytoplasmic expression of YFP altered the phenotypes associated with inhibition of σE.
To address the question whether expression of EGFP MTA1 altered the expression of these proteins, immunoblot analyses were performed.
Figure 7b shows that expression of dMFN altered the distribution of GFP-Reaper.
We also found the gene expression of JUND altered in high-grade tumours.
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