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Local production of antigen-specific IgE in allergic fungal rhinosinusitis (AFRS) is likely integral to the expression of allergy.
Early gut microbial colonisation is associated with modulation of inflammation and expression of allergy.
High serum IgE levels have been reported to be correlated with the clinical expression of allergy and asthma, and a strong genetic component has been shown to contribute to this association [ 7, 8].
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Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes.
We had also explored whether there was any association of CCR8 expression with serum markers of allergy (IgE and eosinophils) in both asthmatics and normal controls.
An ideal study would follow allergy-prone compared with non-allergy-prone infants from late pregnancy until late childhood and test for the expression of all forms of allergy, as well as sensitivity, using a standardised protocol.
We assessed the role of CD14 C-159T, G-1359T in the expression of asthma, croup, and allergy in Canadian school children of ages 6 to 14 years.
To test these hypotheses integrated analysis of a large number of gene expression microarray experiments from different forms of allergy was performed.
Alam, SM, Crispe, I, and Gascoigne, N. "Allelic exclusion of alpha-chain TCR: Analysis of dual alpha-chain expression in immature and mature thymocytes". JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 99, no. 1 (January 1997): 798-798.
A similar correlation between certain allergic responses and increased IFN-γ expression has been reported in human clinical studies of allergy; this pig model of allergy may be indicative of potential probiotic modulation of allergic lung disease in humans.
In a recent report Krogulska et al. [ 16] suggested a possible protective role of Foxp3 and IL-10 in food allergy, where the expression of these genes was up-regulated in children who were developing tolerance to allergenic foods.
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