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We identified a remarkably elevated expression of a spectrum of genes involved in Immunity and Defense in PBMCs of RA patients compared to controls.
We observed an elevated expression of a spectrum of genes involved in Immunity and Defense, nucleoside, nucleotide and nucleic acid metabolism, signal transduction, protein metabolism and modification, mRNA transcription, transport and developmental processes in the peripheral blood of RA patients compared to controls.
In response to environmental cues, BvgAS controls expression of a spectrum of phenotypic phases transitioning between a virulent (Bvg+) phase and a non-virulent (Bvg-) phase.
Gene expression in Bordetella is regulated by a two-component sensory transduction system, BvgAS, which controls the expression of a spectrum of phenotypic phases transitioning between a virulent (Bvg+) phase and a non-virulent (Bvg-) phase.
Together, these observations point to a general mechanism of cell-surface plg binding in which total binding is determined by the collective expression of a spectrum of heterogeneous receptors and proteolytic activity.
HIF-1α and NF-κB are key transcription factors that respond to changes in cellular oxygenation and that orchestrate the expression of a spectrum of genes that are critical to the persistence of the synovitis.
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Thus, FHL2 participates in regulating expression of a large spectrum of genes involved in cell proliferation, differentiation, transformation and apoptosis.
The phosphorylation of ATF-2 thus results in the expression of a broad spectrum of proteins implicated in different processes, such as cell cycle molecules (cyclin D1) [56], cell adhesion molecules [57], growth factors [58], anti-apoptotic factors [59], and invasion-related molecules [60].
As a kind of ubiquitous transcription factor, bZIP proteins regulate the expression of a wide spectrum of stress-related genes.
Our results reveal alterations in the expression of a diverse spectrum of genes, reflecting changes in various components of key signaling pathways involved in tumorigenesis.
Thus, like PXR, CAR influences the expression of a broad spectrum of transporters and enzymes involved in drug and in bile acid transport and metabolism.
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