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To overcome the potential limitation from use of cell lines vs. intact tumors, we compared expression of a restricted, recurrently enriched signature from the hemangiosarcoma cell lines to whole tumor tissues.
The malignant cells of these tumors sustain non productive EBV infections characterized by the expression of a restricted set of viral genes that, in different combinations, define three types of viral latency.
Another is to identify objective indicators of poor well-being in severe dementia, for example, confinement to home and expression of a restricted range of positive emotions [ 16, 89].
Moreover, upon treatment with DDD00015314, the cells underwent a change in expression of a restricted set of genes, many of which are also elevated upon stumpy formation in vivo.
LN results from the organized aggregation of T and B cells around specialized vessels known as high endothelial venules (HEVs), and correlates with the ectopic expression of a restricted set of homing chemokines, which are physiologically involved in the traffic and tissue compartmentalization of T and B cells in secondary lymphoid organs [ 6].
Although the COO classification allows the division of DLBCL based on expression of a restricted set of classifier genes into the two principal classes [ 24], a subset of cases show patterns of classifier gene expression that do not allow confident assignment to either GCB or ABC subsets.
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Freedom of expression is a restricted right, available only to powerful men.
For example, it has been demonstrated that species-specific differences in tentacle formation in the cnidarian genus Hydra correlate with expression of a taxonomically restricted gene encoding a small secreted protein of ∼85 105 amino acids [13].
Within NKT-cells, the most extensively studied subset are the invariant NKT (iNKT) cells, which are defined by their expression of a highly restricted TCR and their potent activation by the α-galactosylceramide (α-GalCer) ligand.
While Epac1 is widely expressed mammals, the expression of Epac2 is restricted to a few tissues including the adrenal gland [14], [15].
We downloaded raw file containing tissue-specific UniGene lists and mapped this information, i.e. whether the expression of a gene is restricted to a single tissue, using gene symbol to UniGene maps from the same provider.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com