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However, such coefficients do not specify whether the expression of all genes was slightly changed or whether the expression of a proportion of genes was altered dramatically.
Expression of a proportion of these NATs has already been confirmed by other technologies while the true existence of the remaining ones has to be validated.
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Since the expression levels of a large proportion of human genes have a strong genetic component [ 33- 35], the correlation in RE-score between parents and offspring could simply reflect the correlation in the expression levels of a proportion of the genes targeted by the miRNA.
In our study, expression of a small proportion of genes was found to be correlated to methylation and another small proportion was correlated to copy number changes seen in CRC.
Cis-acting variation in the expression of a high proportion of genes in human brain.
Further analyses identified signal transducer and activator of transcription 3 (STand) and CAATT/enhancer binding protein-β (CEBPβ) as potential master regulators that control the expression of a substantial proportion of these mesenchymal genes.
Bioinformatic predictions and a wealth of data from wet laboratory studies indicate that miRNAs control expression of a large proportion of protein-coding genes, implying involvement of miRNAs in regulation of most biologic processes.
In murine cells, a recent study of gene expression of a significant proportion of TRIM proteins and an additional microarray study provided some insight into the expression of this protein family in mouse [34], [35].
The expression of only 176/11,783 (1.5%) genes was correlated (p<0.008, FDR = 25%) in the two tissue types, but expression of a high proportion (20 of these 176 genes) was significantly related to cis-SNP genotypes (adjusted p<0.05).
Statistical analysis of gene expression indicated that expression of a large proportion of the "structure" and many of the "lipid metabolism" genes were normalized in VAT and SCAT of obese mice.
The higher number of genes detected as expressed in males may be explained by sex-related differences in gene expression, as we detected expression of a higher proportion of sex-biased genes in males than in females (see Discussion).
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