However, both Kd values are some 20-fold lower than that for the monoarsenical PSAO, consistent with the expression of a very modest chelate effect with these bis-arsenicals.
In our first analyses, we required reasonable levels of expression, a modest (>= 1.7) fold change, and a nominal P < 0.05.
Despite marked reductions of BDNF expression, only a modest impairment of epileptogenesis and increased hippocampal TrkB activation were detected in BDNF mice.
Expression of SOX17, GATA4 and GATA6 showed a strong induction under our conditions (500 to 1000 times GAPDH expression), while expression of AFP showed a modest level of induction.
Manipulation of MKRN1 expression had a modest, yet statistically significant, effect on the abundance of early apoptotic markers in NaAsO2-stressed ESC populations (Fig 6A and B).
When we compared the expression by groups, a modest increase of MIF mRNA expression was observed in the carriers of the C/C genotype compared to the G/G genotype in both groups).
Similarly, when we compared the expression by groups, a modest increase of MIF mRNA expression was observed in the 6,6 carriers in both groups, while the 7,7 carriers had a low expression in the obese group.
Cx43 does not seem to be particularly sensitive to eIF4E (nor mTOR nor Mnk1/2) as knocking down the cap-binding protein eIF4E (moderately) by siRNA does not strongly affect its expression levels although a modest reduction of GJA1-43k, and particularly of GJA1-20k, is observed (Additional file 3: Figure S2D).
Studies have suggested that, unlike with mRNA expression, a modest number of ∼200 microRNAs might be sufficient to classify human cancers (15).
The BD-L metagene was derived from changes in gene expression due to a modest overexpression of BRCA1 within a single cell line.
