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In contrast, DOCK2 is expressed specifically in hematopoietic cells, while DOCK3 expression is primarily restricted to the brain and spinal cord [34], [35], [36].
In the embryo, Hlp expression is primarily restricted to the developing heart.
CTLA-4 is a type 1 transmembrane glycoprotein whose expression is primarily restricted to T cells [17].
UP expression is primarily restricted to the urothelial compartment of the urogenital tract.
Further co-localization studies with Runx1 confirmed that their expression is primarily restricted to nonpeptidergic nociceptors (data not shown).
In normal cells, expression is primarily restricted to mesothelial cells in the pleural, pericardial, and peritoneal membranes.
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In murine tissue slides, cofilin-1 expression was also visible in synaptopodin negative glomerular cells, whereas cofilin-1 expression was primarily restricted to podocytes in human glomeruli.
By adulthood, bronchiolar cell numbers were decreased and Sox2 was absent in extensive regions of the bronchiolar epithelium, at which time residual Sox2 expression was primarily restricted to selective niches of CGRP staining neuroepithelial cells.
EGFP/L10a expression was primarily restricted to superficial layer 2/3 in the mPFC, including the prelimbic, infralimbic and medial orbitofrontal regions.
At postnatal stages, Cux2 expression was primarily restricted in a subset of Nestin and Sox2 double-positive NPs (Fig. 3).
In normal mammary tissue, PDI expression was primarily restricted to the myoepithelial cells and, while most (14/16) BH tissues maintained this myoepithelial tissue distribution, this distinctive staining pattern was lost in DCIS (9/15) and IBC (20/22) (data not shown).
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