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Although the KSHV genome is known to encode for homologs of several human chemokines and a G-protein coupled receptor (vGPCR) [4], the potential contribution of these proteins to the disease pathogenesis is limited by the fact that their expression is generally restricted to the lytic-phase of viral life-cycle and is observed in <1% of latently-infected PEL cells [24], [25].
In normal tissues, expression is generally restricted to testis.
CD33 (Siglec-3) is a sialic acid activated receptor whose expression is generally restricted to myeloid cells.
As shown in Figure 3, histamine treatment is accompanied by increased density of neurons expressing vimentin (indicated by red arrows, Figure 3(b) versus Figure 3(a)) while vimentin expression is generally restricted to vascular endothelial cells in untreated samples.
Matrix metalloproteinases are required for peritumour tissue degradation and metastasis (Overall and López-Otín, 2002), and their expression is generally restricted to aggressive lung-metastatic populations of cancer cells (Minn et al, 2005).
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The expression was generally restricted to the upper layers.
K5 expression was generally restricted to the ductal cells throughout embryonic and postnatal development, consistent with previous studies suggesting that progenitor cells reside in the ducts in mature submandibular glands (Denny et al., 1997; Man et al., 2001; Lombaert et al., 2008).
In contrast to the broad ectodermal patterns expressed during larval development, Capitella Hox gene expression in juveniles is generally restricted to the VNC (Figure 13), with a few notable exceptions (see below).
While expression of these transcripts is generally restricted to the brain, in tumours ectopic expression is observed.
The expression of MHC class II molecules is generally restricted to professional antigen-presenting cells, so as to regulate the initiation of responses by CD4+ T helper cells.
However, although the expression in myeloma expression usually encompasses a majority of plasma cells, immunopositivity is generally restricted to only few plasma cells in amyloidosis.
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