However, these models cannot determine if increased ICOS surface expression is contributing to disease progression or alternatively, if it is a result of augmented T cell activation.
Thus the strong transcriptional effect of MYC that we have detected suggests that more than altered MYC expression is contributing to its activity in basal breast cancer.
The lack of differential gene expression of these anabolic growth factors in our study is most likely due to the gene expression being contributed by the various cell types present in the bone microenvironment.
Taking all of these 1,863 differentially expressed genes in FFPE samples into account, we found that overall 30.32% of the variation in individual gene expression was contributed by "storage" (FFPE or FF), 4.94% by tissue type (tumor or normal), 25.43% by "person-to-person" variation and the rest 39.31% of the variation could not be explained by the ANOVA model.
We note that despite these arguments it is possible that some, but presumably not the majority, of the noise at intermediate expressions is contributed by unknown extrinsic factors.
It is known that changes in microRNA expression are contributing to cellular senescence [ 16] and organismic aging [ 17, 18]; however, the role of microRNAs, if any, in UVB-induced senescence of human fibroblasts is only poorly understood.
In contrast, high HULC expression level is contributed to a better disease-free survival in HCC patients (mean survival time, high = 62.37 ± 4.73 and low = 40.98 ± 4.46 months, resp.; log rank P < 0.001, Figure 2(B)).
Variation in microarray-based, single cell expression measurement is contributed to by (i) technical noise intrinsic to the microarray platform; (ii) sampling effects caused by non-representative amplification of low abundance mRNA transcripts; and (iii) real differences in gene expression levels between two samples.
The gene expression level data is contributed by the authors of [ 33].
These results suggest that the increase in miR-223 expression following MTD stimulation is contributed by Ly6G+ cells from the haematopoietic system.
