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A proportion of genes identified as significantly differentially expressed were selected for verification by QPCR, on the basis of robust microarray data confirming differential gene expression, involvement in a biological process identified as enriched by GO analysis, or a known function in neurodegeneration.
Because of the complexity of vitamin A metabolism, the precise role of CRBP-1 in retinoid signaling remains controversial, despite numerous studies conducted over the past three decades on its binding properties, three-dimensional structure, tissue localization, regulation of expression, involvement in retinal metabolism, and null mutation [ 120].
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Circadian clock genes may be influencing disease susceptibility due to their pleiotropic activities on gene expression or involvement in other pathways, rather than through their involvement in circadian clock function.
James had previously expressed antislavery sentiments, but Maria urged him towards more active expression and involvement.
She also won a Presidential Early Career Award for "scholarly work in cancer-related studies of cell growth and gene expression and involvement of undergraduate, graduate and especially minority students in the discovery process".
This might be attributable to lower levels of TNF expression, the involvement of other proinflammatory cytokines and/or the development of neutralizing antibodies against the TNF blocking agent during treatment.
An analysis of data available on biological effects of altered gravity at the cellular level allows one to conclude that microgravity environment appears to affect cytoskeleton, carbohydrate and lipid metabolism, cell wall biogenesis via changes in enzyme activity and protein expression, with involvement of regulatory Ca2+ messenger system.
Twenty three genes with altered expression and involvement in presynaptic vesicular transport, Golgi function and GABAergic neurotransmission define a unifying molecular hypothesis for dysfunction in cerebellar cortex in SCZ.
In the present study, we have further characterized the Y. pestis pcm locus genes and analyzed their expression and involvement in the pathogenesis of Y. pestis using mouse models of bubonic and pneumonic plague.
However, expression and involvement of IL-34 in IBD remain unknown.
In contrast, Stat5b protein levels remained unchanged, suggesting divergent expression and involvement of Stat5a and Stat5b during breast cancer progression.
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