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Proteomics can potentially capture dynamic changes in protein expression integrating both genetic and epigenetic influences.
For sustained transgene expression, integrating vectors, like viruses [ 3] or nonviral systems based on integrases or transposons have been utilized [ 4, 5].
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From this analysis, 319 genes (hypergeometric p-value < 0.0001) which showed lethal or unfavourable growth on performing single gene deletions for the gene expression integrated models were selected as candidate essential genes (Additional file 1: Table S1).
The aim of this study was to investigate tissue-selective expression patterns, integrating publicly available gene expression data.
The authors have gone the extra length to control for differential transgene expression by integrating transgenes at a single expression locus.
To obtain more information on the activity of the pathways which showed aberrant mRNA expression, we integrated mRNA expression data with data obtained with kinase PamChip® peptide microarrays.
Retroviral vectors are commonly employed for long-term transgene expression via integrating vector technology.
Thus, cells would modulate gene expression by integrating AJ status with Wnt-like external signaling.
In this study, we have identified three novel downstream elements that regulate MHC class I gene expression by integrating regulatory signals on specific transcription start sites.
We constructed predictive models of gene expression by integrating RNA-sequencing, TF and HM chromatin immunoprecipitation sequencing and DNase I hypersensitivity data for two mammalian cell types.
Therefore, the fate of IbWRKY regulates the sporamin gene expression via integrating SA and JA-signaling events, depending upon the stress.
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