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Analysis of diploid ES cells containing the X-linked GFP transgene shows robust GFP expression, indicating that the transgene is properly expressed in ES cells.
TAG1 is expressed in ripening fruit and induced in the absence of TAGL1 expression, indicating possible functional redundancy.
Age-associated changes also prominently coincide with increasing variance in gene expression, indicating a possible degradation of regulatory homeostasis.
We then observe these embryos for changes in specific marker gene expression, indicating changes positive or negative in cell-fate.
Our results with O-GlcNAc inhibitors showed for the first time that O-GlcNAcylation directly regulates FoxO1 expression, indicating that FoxO1 expression is O-GlcNAc dependent.
We found that RH30 cells depleted for EZH2 showed MyHC expression, indicating that depletion of EZH2 could promote differentiation (Fig. 6a).
The proband's tumor demonstrated high-frequency microsatellite instability and displayed loss of hMLH1 expression, indicating bi-allelic inactivation of hMLH1.
This induction was largely related to parenchymal cell TLR4 expression indicating a parenchymal cell driven inflammatory response in these two organs consistent with the parenchymal TLR4 dependence of the LPS-induced host systemic inflammatory response.
Our findings demonstrate that miR-214 may simultaneously regulate the two target sites of the LHX6 3′ UTR region to mediate LHX6 expression, indicating that LHX6 is a direct target gene of miR-214.
Notably, donor T cells in CTX-treated mice did not downregulate IL-7Rα expression, indicating that host-derived IL-7 in CTX-treated mice does not reach the level of IL-7 in Rag2KO mice.
A further deletion at position −76 completely abolished luciferase expression, indicating that region −154/−76 contains the critical regulatory element for functioning of the TTV promoter.
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CEO of Professional Science Editing for Scientists @ prosciediting.com