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The finding of a significantly reduced chemokine CXCL-5 expression indicates reduced parenchymal inflammation and, therefore, reduced neuronal stress.
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Low p-mTOR expression was associated with treatment benefit (P = 0.00003; Fig. 1a), whereas high p-mTOR expression indicated reduced response to treatment (P = 0.55; Fig. 1b).
Moreover, high CXCR4 expression indicated reduced overall survival (OS) in the training (P<0.001) and validation (P<0.001) sets, especially for patients with early-stage (TNM stage I+II) diseases.
Stimulation of HUVEC with the adsorbent-treated plasma resulted in significantly diminished release of IL-6, IL-8, PAI-1 and decreased ICAM-1 and E-selectin expression, indicating reduced HUVEC activation.
IR caused a pronounced increase in HSP70 protein levels by day 2, while application of BIRB796 dramatically decreased the effect on HSP70 expression, indicating reduced incidence of AKI with this treatment.
Under normal growth, these pathways reach transcriptional peaks during the early stages of the IDC, so down-regulation indicates reduced expression in young parasites.
Our finding which indicates reduced expression of caspase-3 in sperm of diabetic rats following C. borivilianum root extract treatment suggested that increased sperm viability was due to decreased in apoptosis.
3) Although the flow cytometry data in Figure 5C indicates reduced surface expression of VEGFR2 this seems only to be the case for around 50% of the cells.
However, gene expression analysis of Jo2-treated Mmp12−/− mice indicated reduced expression of genes implicated in fibroblast migration and proliferation, suggesting that MMP-12 contributes to fibroblast activation.
Fascaplysin treatment indicated reduced expression of cyclin D1 and Cdk 4 and a reduced G0-G1 wheneas when cells were treated with thymidine, the cells showed an increase in G0-G1 along with increased cyclin D1 and Cdk 4 expression levels.
Negative fold-change values indicate reduced expression level in diabetes-exposed embryos.
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