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The metallothionein TC cluster contains a gene (pKIWI504) previously identified in kiwifruit [ 24] as being highly expressed in young fruit with reduced expression in the later stages of fruit development.
But even if that is so, the idea undoubtedly finds its fullest expression in the later work).
Thus, it could be that the microarray positive results refer to this zinc finger protein and not to CNTF, explaining why we did not observed any CNTF expression in the later PCR analyses.
Therefore, it seemed reasonable to turn this approach around to identify candidate genes involved in late stages of IES elimination by searching for genes with distinctive patterns of expression in the later stages of conjugation.
Activation of various IFN regulatory mechanisms such as up-regulation of negative regulators, SOCS via JAK-STAT signaling may lead to the suppression of IFN and/or other anti-viral gene expression in the later stage of virus infection and therefore provide the virus with additional time to replicate.
The same observation holds for COL1 expression in the early passages, but not for COL1 expression in the later passages.
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Early stage breast cancer showed expression of Survivin-2B, but there was low or no expression detected in the later stages of the tumors.
It was reported that NRG-1/ErbB expression declined in the later stages when pump failure occurred [ 31], The decline in NRG-1 expression coincided with the development of eccentric ventricular hypertrophy and pump failure and was accompanied by a down regulation in the mRNA levels of ErbB2 and ErbB4.
In the early phase, genes related to transcriptional regulation and the maintenance of signal transduction were activated, and then the expression diminished in the later phase.
Although TaLCYB had a higher expression level in the later stages of grain development, the β-carotene content still showed a decreasing tendency.
Post normalization of the data, an apparent elevated expression level in the later time points, therefore, indicates slow degradation relative to the genome-wide mean rate of RNA decay.
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