An aberrant CpG methylation reduces miR-34 family expression in multiple types of cancer, including PDAC [ 116].
We interpret these observations to mean that the H3K36me3 H3K27me3 gene body signature is a general feature of monoallelic expression in multiple types of human cells, while a particular set of affected genes can be cell type-specific.
For this purpose, we chose to investigate the profile and characteristics of fibers in sciatic nerves, a nerve trunk that contains a mixture of motor and sensory fibers, thus enabling direct comparison of JAM-C expression in multiple types of fibers.
In addition to the role of miR-200c and miR-141 in the phenotypic conversion of normal cells, dysregulation of normal patterns of miR-200c expression occurs in multiple types of cancer cells and is linked to tumor progression [2], [6], [12], [13], [14], [15].
Recently, the increased expression of APP in multiple types of cancers has been reported where it has significant correlation with the cancer cell proliferation.
The altered expression patterns of DDR2 mRNA expression have been reported in multiple types of human cancer, including NSCLC [ 16, 17].
We observed that PPAR γ expression is usually underexpressed in multiple types of thyroid tumours, and that this may be an important event in the development of thyroid neoplasias.
Over expression of IGF-II is reported in multiple types of cancer and is proposed as a potential mechanism for cancer cells to develop resistance to IGF-1R-targeting therapy [ 42].
The high expression levels of claudin-3 and -4 in multiple types of cancer may provide a unique opportunity for anticancer therapy using CPE.
Elevated YAP expression and nuclear localization have been observed in multiple types of human cancers, including liver cancer, colon cancer, epithelial ovarian cancer, lung cancer, and prostate cancer (Overholtzer et al, 2006; Zender et al, 2006; Dong et al, 2007; Yuan et al, 2008; Zhang et al, 2009; Hall et al, 2010; Jemal et al, 2011; Hergovich, 2012; He et al, 2015).
We examined gene expression level after 6-h treatment with CY or SAHA in multiple types of cancer cell lines.
