Unexpectedly, we also observe an association between decrease in mean expression and increase in coexpression, while increase in mean expression does not appear to correspond to a change in coexpression.
At the threshold value and above, 205 genes expressed in ES showed coexpression with their neighbors.
Then how does decrease in mean expression correlate with increase in coexpression?
In contrast, mutant SOD1 expression in MN and coexpression in MN+glia enhanced climbing ability in flies.
Despite sex-biased expression in genes associated with the extracellular region and structural molecule activity, the gene coexpression networks are largely similar between the sexes.
We found that changes in expression variability are associated with changes in coexpression patterns.
The results suggest that changes in expression variability are associated with changes in coexpression pattern, which imply that DV is not merely stochastic noise, but informative signal.
For example, in ([ 54], Ho et al., 2008) it was clearly indicated that changes in expression variability were associated with changes in coexpression pattern, which implied that DV was a signal rather than a noise.
In this study, we devised a ranking system that uses these type 2 diabetes expression traits in combination with coexpression networks in metabolically important tissues to discover novel genes associated with type 2 diabetes.
Our analyses further indicate that the expression pattern of the C-subfamily of V2Rs (expression in most VNO sensory neurons and coexpression with subfamily-ABD members) is conserved in squamate reptiles, hinting at an important functional role played by this coexpression strategy.
