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Another important constraint in protein evolution is the protein expression; highly expressed proteins are more conserved than others proteins [ 5- 8].
The evolutionary rate of the protein-coding genes shows a universal negative correlation with expression: highly expressed genes are on average more conserved during evolution than the genes with lower expression levels.
According to selection for economy of gene expression, highly and quickly expressed genes can be expected to experience stronger selective forces for shorter introns.
Attachment to the plasma membrane by linkage to a glycosylphosphatidylinositol (GPI) anchor1 is a mode of protein expression highly conserved from protozoa to mammals2.
Importantly, cyclin D1b expression highly correlated with that of Slug in clinical samples of advanced disease.
This observation showed that a learner's positive emotions were affected by the agent's enthusiastic verbal and nonverbal cues, such as smiling facial expression, highly animated gestures, enthusiastic vocal tones, and remarks indicative of interests towards the subject, which then enact approach behaviours in the learning process, particularly in terms of affective perceptions and motivations.
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Expressions highly objectionable by Times standards were printed because of the light they shed on a historic matter, the possibility of a presidential impeachment.
These showed that lowering αV, β1, β3 or β5 expressions highly affected the echistatin uptake (Additional file 1: Figure S2).
In contrast, FOXM1 expression was highly expressed in both dividing and non-dividing UK1 cells.
The strongest correlate of evolutionary rate is expression level: highly expressed proteins tend to evolve slowly.
A number of studies and observations confirm that heterosis often is expressed for plant height, but the expression is highly cross specific.
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