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The online survey comprised 16 pages of 31 questions designed to measure participant views on data classification (Figure 2), map content (Figure 3), key expression, hazard curves (Figure 4), map colour scheme (Figure 5), explanatory text (Figure 6), and map format.
In the univariate model, initial stage at diagnosis, number of colorectal liver metastases, margin and CIP2A expression (hazard ratio [HR] = 1.447, P = 0.049) were prognostic factors.
Patients with high BHRF1-1 expression levels had an increased estimated risk of death when compared to those with low relative expression (hazard ratio [HR] = 5.947; 95% confidence interval [CI] = 1.86, 19.015, p = 0.002).
In contrast, both IDO expression (hazard ratio=12.04, P=0.020) and FIGO stage (hazard ratio=4.52, P=0.009) were found to be independent prognostic factors with respect to PFS on multivariate analysis (Table 3).
In addition, positive ALDH1A1 expression patients were almost 2.0 times more likely to suffer from relapse than those with negative ALDH1A1 expression (hazard ratio, 1.945; 95% CI, 1.346 - 2.812).
Multivariate analysis showed that PRL-3 expression (hazard ratio [HR] = 1.609; P = .035), cytogenetic risk (HR = 2.143; P = .014), and CD34 expression (HR = 2.089; P = .000) were also independent predictors for DFS, respectively, but no CD7 expression.
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On multivariate analysis using binary logistic regression, including grade, size, lymph node, HER2 and ER status, only negative ER significantly correlated with HIF-1 α expression (P=0.039, Hazard ratio=0.289, 95% CI for hazard ratio 0.089 0.941).
Furthermore, a Cox regression analysis revealed the cIAP2 expression status (hazard ratio, 4.91; P=0.037) and the pathological response to chemoradiotherapy (hazard ratio, 0.418; P=0.016) to be significant prognostic factors for OSCC patients.
Multivariate analysis using the Cox regression model revealed that the cIAP2 expression status (hazard ratio, 4.91; P=0.037) and the pathological response to preoperative chemoradiotherapy (hazard ratio, 0.418; P=0.016) were significant prognostic factors for the survival of OSCC patients (Table 2).
The multivariate analysis identified ERCC1 mRNA expression levels (hazard ratio (HR), 9.4; P<0.0001) and number of sites involved (HR, 1.9; P=0.03) as independent markers for survival (Table 3).
Statistical analysis showed that distant recurrence was more common in the patients with Gli-1 nuclear expression (P=0.002, hazard ratio 4.115, 95% confidence interval (CI) 1.676 10.104).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com