Post-transcriptional regulation of syndecan-1 expression has been indicated previously, for example in pancreatic cancer and peritoneal macrophages [ 34, 39, 41].
ERβ is the predominant subtype of estrogen receptor in colorectal epithelial cells; its loss of expression has been indicated as a common step in the development of CRC [ 6, 16- 18].
In addition, several MMP transcript expression levels have been indicated to be associated to platinum-resistant head and neck cancer cell lines (Ansell et al, 2009).
TMAs have been used to validate immunohistochemical expression profiles of proteins that have been indicated as predictors for laryngeal carcinoma [ 52, 53].
Nested PCR was then carried out, seeking to amplify transcripts from four genes, the expression of which had been indicated by both microarrays (mRNA) and mass spectrometry analysis (protein).
Estrogen receptor beta is the predominant subtype which mediates the biological effect of estrogens, while loss of expression of estrogen receptor beta has been indicated as a common step in the development of colorectal cancer (CRC).
In the study by McGowan et al. [ 65], significant hypermethylation in the promoter and 5′ regulatory region of ribosomal RNA (rRNA) gene in the brain of suicidal individuals with history of early childhood neglect/abuse, consistent with decreased rRNA expression levels in the hippocampus, has been indicated relative to the control subjects.
More importantly, the aberrant expression of GOLPH3 in these cancers has been indicated to be correlated with clinically aggressive behaviour and patient survival.
It has been indicated that CDH11 expression may be useful as a prognostic marker of disease progression and survival in osteosarcomas [ 7].
Actually, it has been indicated that the expression of β-endorphin sensitive receptor on skeletal muscle is vastly increased in type 1 and type 2 diabetic animals [ 38, 39].
