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This directional relationship between replication timing and gene expression has been observed in development and differentiation11,14,15.
Toll-like receptor (TLR) expression has been observed in the testis, epididymis, prostate and vas deferens.
The set of TFs proposed by the design algorithm do not necessarily include all those whose expression has been observed in real infections (Figure 5A, lower panel).
Increased GNA13 expression has been observed in metastatic breast cancer cells.
No Tbr1 expression has been observed in the ventricular zone.
Increased MAFB gene expression has been observed in myeloma [33].
Interestingly, IFNλ expression has been observed to be important for human hantavirus infection in vivo.
Heterogeneous protein expression has been observed as early as E14.5 [9].
In the mouse embryonic kidney, for example, strong Tim expression has been observed in regions of active ureteric bud branching.
Increased Ctgf expression has been observed in conjunction with fibrotic pathology in a number of organs and disease conditions.
The dysregulation of miRNA expression has been observed in cells obtained from various cancers [13], [20], [22].
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