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miRNAs are regulators of early development, cell fate determination, differentiation, proliferation, apoptosis [37] [39] and dysregulation of their expression has been involved in various human diseases such as cancer [40] [44], developmental abnormalities [45], muscular disorders [46] and inflammatory diseases [47] [51].
Galanin's expression has been involved in many cancers.
In the pancreas, SOX2 expression has been involved in invasion and metastasis of pancreatic intraepithelial neoplasia [ 8].
Galanin is a neuropeptide which belongs in a family of peptides whose expression has been involved in many cancers [ 13].
Germ-line mutations in this gene predispose to breast and ovarian cancer, and its expression has been involved in differential CRC prognosis.
Altered miR-107 expression has been involved in several cancer types, including head and neck squamous cell carcinoma (HNSCC), ovarian, gastric or breast cancer, among others [ 25– 27].
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In macrophages, HIV PIs activate the unfolded protein response (UPR) which is involved in the regulation of CD36 expression an event that has been involved in foam cell formation [11].
The aberrant expression of enpp family has been involved in cell motility and migration, angiogenesis, tumor cell invasion and bone mineralization dysfunction but the underlying mechanisms largely remain to be determined [31].
Since 4T1 tumors are characterized by strong expression of IL-6, which has been involved in the regulation of arginase-1 expression [ 44, 45], the possible role of this enzyme was evaluated.
The dysregulation of gene expression in the TNF-TNFR superfamily has been involved in various human cancers including non-small cell lung cancer (NSCLC).
Abnormal expression of ACSL4 in non-steroidogenic tissues has been involved in tumorigenesis [3], [4], [6].
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