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Similar hypotheses might also be relevant to Hodgkin lymphomas where galectin 9 expression has been initially reported and which is associated to EBV in about 50% of the cases with consistent and intense expression of LMP1 [ 17, 41].
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Of note, an other interesting issue would consist in determining whether modified tubulin expressions have been initially selected in HME1 cells because of their paclitaxel-resistance properties or whether they result from paclitaxel-induced aberrant but viable phenotypes.
The ectopic expression of ΔNp63 isoforms has been initially reported to inhibit p53 transactivation, leading to the early speculation that overexpression of ΔNp63 might simply be a mechanism to inactivate p53 [21] [21].
In AD patients, the EC could be the region from which the pathological process spreads towards other brain regions; this has been initially hypothesized because expression of APP, the precursor of β−amyloid, was higher in EC layer II neurons than in other brain areas.
NGAL has been initially introduced in patients undergoing cardiosurgery.
All mammalian cells express the initially characterized AZIN1, whereas AZIN2 expression has been reported to be most abundant in brain and testis [19].
CA9 was initially identified in HeLa cells [ 18]; its expression has been found in a variety of tumor types including colorectal cancer [ 19].
Although initially described in NK cells, DAP12 expression has been reported in various hematopoietic cells such as osteoclasts, neutrophils, macrophages and dendritic cells [4].
Gbx expression has been described previously [57].
The cases when snoRNA expression was not detected in human look particularly odd considering that all these snoRNAs have been initially described in human (Additional file 1).
Associated anterior cruciate ligament tears might have been initially overlooked.
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