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Thus, we excluded genes that had a large basal expression fluctuation.
Its expression dynamics also includes the expression fluctuation in different stages.
Yang et al. [ 20] have proposed genetic buffering roles of for human microRNAs (miRNAs) on genome expression fluctuation.
However, one potential limitation of the approach is that some relevant genes and transcription factors that do not have significant expression fluctuation may be missed by the analysis.
The plant leaves were collected at the four-leaf stage at the same time-point to avoid the effect of expression fluctuation during the day.
Accordingly, this expression fluctuation was also seen in Molognoni et al. [ 27], showing that Ezh2 might be involved in the primary events of melanocytes transformation.
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Thus, such number of differentially expressed genes could be attributed to "normal" gene expression fluctuations or differences.
Here, we use optogenetics to investigate how the pluripotency network in embryonic stem cells (ESCs) achieves a robust response to differentiation cues but not to gene expression fluctuations.
This enrichment becomes one of the driving forces for the emergence of the network scale-free topology, enables the network to adapt quickly to environmental changes and mitigates gene expression fluctuations.
Thus, our work also reveals the regulation by correlations in gene expression fluctuations [33].
Regulatory interactions can be revealed by analyzing dynamic correlations in gene expression fluctuations [20].
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