Sentence examples for expression exerted from inspiring English sources

While wt-PDX1 expression exerted small effects on blood glucose levels, treatment with PDX1-VP16 adefficientlyfinducedy insulin insulin production in hepatocytes, resulting in reversal of STZ-induced hyperglycemia.

Hence, the beneficial role of H3R in limiting disease expression by controlling histamine release and metabolism is highlighted by the higher therapeutic effectiveness and better control of inflammatory gene expression exerted by H1R and H2R inhibitors when H3R is functional.

Nevertheless, the major characteristic differences between some of the donors were clearly maintained over time, for example, low NKp30 expression exerted by donor AZ was stable and remained very distinct from either donor AK (displayed high FAB) or donor YC (displayed high percentage) (Figure 4).

Consistent with our published data [5], ERβ expression exerted at any considered time a significant (p<0.05) suppressive effect on MSTO-211H cell proliferation (Fig. 1C), without inducing apoptosis (data not shown); we believe that in these cells PI3K/Akt could act in concert with MAP kinase signaling to modulate cyclin D1 expression and cell cycle progression.

Mirkin et al (2005) reported that increased MK expression exerted a significant cytoprotective effect against doxorubicin in drug-sensitive cells.

Eigensystems conserved between stroke and seizures separate effects of different biological processes on gene expression, exerted via distinct sets of transcription factor binding motifs.

This data suggests that Src64B expression exerts an additional effect on ab-expressing cells to inhibit Dll gene expression and differentiation.

Defects in P53 function lead to impaired transactivation of SCO2, a mitochondrial protein required for the correct assembly of the cytochrome c oxidase in the ETC and of TIGAR, an isoform of 6-phospho-fructo-2-kinase, whose expression exerts a tumor suppressor function by inhibiting glycolytic flux [122, 123].

While the high specific activity allows for an efficient cofactor recycling even with a low level of expression (exerting lower metabolic burden onto the cells and making it more suitable for enzymatic cascading), the low K M-value, on the other hand, allows the enzyme to immediately react with a small amount of glucose and NADP+ present in vivo.

Also, we have shown that TK expression exerts a powerful cytotoxic effect on dog GBM cells [21], [22].

It suggests that cell surface TLR3 on macrophage, but not the intracellular expression, exerts a crucial influence on the pathogenesis of PIA.