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Nuclear S100A7 expression emerged as the most significant prognostic marker for HNSCC (p = 0.006, Hazard's ratio (HR) = 7.6, 95% CI = 1.3 5.1).
BRCA1 mRNA expression emerged as the only significant factor in both the univariate and multivariate analyses of time to progression in the 31 patients receiving second-line therapy (Table 6).
In the multivariate logistic regression analysis of these variables together with RRM1 and disease stage, only low RRM2 expression emerged as an independent predictive factor for response (Table 2).
Most importantly, in our study nuclear PTMA expression emerged as an independent poor prognosticator in multivariate analysis, in comparison with the known clinical and pathological factors for HNSCC including histological grade [well differentiated (WD), moderately differentiated (MD) and poorly differentiated (PD ], T-stage, lymph node positivity and tumor stage.
For example, it was not surprising that the immunoglobulin heavy chain mu constant region is the most distinguishing marker in microarray data for plasma cells circulating in the blood, but CKLFSF2 (Entrez Gene ID 146225) expression emerged as a superior marker for neutrophils and CLIC3 (Entrez Gene ID 9022) for NK cells.
Three patterns of expression emerged.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com