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The majority of the genes that were significantly differentially expressed (differential expression defined as a false discovery rate < 0.05) were up-regulated in the TNFα-treated cells, which is illustrated in the volcano plots in Figure 3B-D.
We analyzed structural features of PK genes associated with breadth of expression (defined as the number of tissues where a gene is expressed).
Normal PMN-CD64, MON-CD64 and MON-Ia expression, defined as the mean ± 2SD of 25 healthy adults after correction for isotype control staining, corresponded to 17 67, 515 1045 and 170 670 AFU respectively.
vWF expression was recorded as 0, 10 or >10 Weibel Palade bodies (WPB) per cell, with high level expression defined as >10 WBP per cell.
In contrast, ER expression (defined as >10% of cells revealing positive staining) was associated with improved RFS and DSS in both cohorts together (RFS; p = 0.070, DSS; p = 0.005) and in the epirubicin (RFS; p = 0.021, DSS; p = 0.008) but not in the paclitaxel (RFS; p = 0.906, DSS; p = 0.196) arm (Supporting Information Figure S2).
Weak expression and strong expression defined as positive staining.
Similar(19)
It focuses on three aspects of communication: self-empathy (defined as a deep and compassionate awareness of one's own inner experience), empathy (defined as listening to another with deep compassion), and honest self-expression (defined as expressing oneself authentically in a way that is likely to inspire compassion in others).
A positive p53 expression was defined as expression in more than 10% of the tumour cells.
The status of gene expression was defined as expression in non-responders compared with responders.
Low Pidd expression was defined as expression at or below that found in normal mucosa, which was 1.2 relative units or less.
High expression is defined as an expression value that is one Median Absolute Deviation or more than the median expression for that particular tissue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com