Sentence examples for expression constraints from inspiring English sources

This indicates that functionally related genes are under similar expression constraints.

We used MANTiS for assessing the expression constraints of duplicates in relation with their age of origin.

In order to obtain information on the organisational and expression constraints of the antigen, we carried out a comparative genomic approach.

One can also suppose that, due to genetic and proteomic redundancies, expression constraints are relaxed within an amphiploid, allowing previously constrained genes to be differentially regulated and to evolve in a different way.

As it has been suspected that genes in multicellular organisms have too many expression constraints to achieve an analog codon choice pattern for the whole genome or for most of the expressed genes [ 17], we hypothesize that translational selection is more pronounced in human genes that are expressed ubiquitously and consistently in most or all tissues.

We did not find a significant difference in tolerance to amino acid change (comparing dN/dS among Saccharomyces sensu stricto species [26] in genes with versus without cis-regulatory variation, data not shown) suggesting that structural constraint does not necessarily predict gene expression constraint.

10.7554/eLife.05462.012 Figure 9. Natural variation in expression constraint and gene copy-number variation.

Larger values represent a higher propensity for CNV coupled with more stringent expression constraint (i.e., small Vg/Vm).

We then asked whether expression constraint, as measured by diversity, changes across lifespan, and whether constraints on expression levels of NEX genes is higher than on ENDEX genes throughout lifespan.

Indeed, the rate of expression divergence (r) under the stabilizing model can be symbolically written by r = σ f, where the expression constraint f < 1 measures the effect of purifying selection.

Genes subject to dosage compensation are under higher expression constraint in wild populations but they show elevated rates of gene amplification, suggesting that copy-number variation is buffered at these genes.