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This indicates even very conserved biological responses elicit different gene expression consequences in the two species.
Furthermore, other studies examining gene expression consequences of oncogene overexpression have reported reduced MAL2 expression in these models [ 39, 40].
We subsequently compared gene expression consequences of smoking in bronchial epithelial cells to those seen in buccal and nasal epithelium.
Further experiments are clearly necessary to compare not only protein expression consequences but also behavioral and drug responses of the Mmu10 trisomic region in the presence of trisomy of the Mmu16 and Mmu17 regions.
With regard to therapeutic strategies, global expression consequences of a transfection reagent and non-coding siRNA might also be harmful by increasing expression of off target genes that have undesired effects.
The goal of this study was to determine which of these mechanisms was plausible in vivo by examining the gene expression consequences in homogenized whole lung of serotonin transporter (5HTT) knockout and heterozygosity as compared to wild-type mice.
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Our data also suggest that the gene-expression consequences of smoking are less pronounced in buccal mucosa (see Figure 3).
Here we report on one aspect, consequences of expression of the hDMPK A isoform, in particular its binding to the MOM.
Although they had no effect on expression, functional consequences of these variants could not be excluded with certainty.
It is currently unknown if the genomic isoforms and their variable levels of expression have consequences at the phenotypic and functional levels of the individual, deserving future investigation.
Fatigue expression and consequences may be modified by cultural differences.
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