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This strategy may allow us to control for gene expression changes introduced by differences in cell populations or genetic backgrounds.
To strengthen this conclusion, we used multiple normalization approaches (i.e., normalized to Rb1-null single mutant control mice, to wild type control mice, and to younger mice with the same genotype) to control for gene expression changes introduced by differences in cell populations and/or genetic backgrounds.
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Close similarities between our cultures and freshly isolated astrocytes in not only levels but also development of aralar protein and mRNA expression [ 34] and in gene changes introduced by chronic treatment with fluoxetine [ 35] support their validity as models of their in vivo counterparts.
Data in the table refer to homo-oligomeric assemblies of the α-subunit, significant changes introduced by co-expression of the β1 subunit are indicated in parenthesis.
Both the test and null model included sequencing platform to discount changes introduced by library construction.
Her order became less restrictive after changes introduced by the Vatican in the 1960s.
Later style changes introduced by Steve Fairbairn in 1881 emphasized leg drive and arm pull.
However when combined, the number of base changes introduced by recombination is much larger than that introduced by mutation.
Collectively, these features identify the changes introduced by Myc on most of its direct target genes.
Reasonable changes introduced by undertaking sensitivity analyses do not significantly change the base-case.
Many computational and experimental studies have also examined flexibility changes introduced by the G121V mutation.
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