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These soluble periplasmic domains may help to prevent aggregation of the unfolded peptide, in a manner that is similar to those of well-folded soluble proteins (e.g., maltose-binding protein), which help fused peptides to stay soluble during recombinant protein expression (Bell et al., 2013).
In addition, the modifications H3K27me2/me3, which are associated with domains of polycomb-mediated repression and the regulation of tissue-specific gene expression (Bell et al. 2010; Kharchenko et al. 2011; Lafos et al. 2011), were negatively correlated with DNA methylation in the fire ant and honey bee (fig. 1).
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Look, bells and whistles!
Bell seems to get -- pardon the expression -- his bell rung on many tackles, only to bounce up as if nothing happened".
In developing seeds, UGT74S1 expression followed a bell curve pattern with peak expression at 16 days after anthesis (DAA).
Taken together, the Wnt5a protein expression exhibited a bell-shaped pattern in human pancreatic cancer tissues.
The percentage of Wnt5a positive expression showed a bell-shaped pattern in pancreatic cancer tissues, peaking in well-differentiated carcinomas.
Although it is also possible that bell-shaped or inverse bell-shaped expression systems are caused by feedback regulatory loops, which may involve genes acting further downstream, 49 primary Oct3/4 target genes that fall into this category are most likely regulated in a similar manner as Zfp42/Rex1.
For Lakoff and Johnson, this non-literal language is not merely peripheral expression useful for adding bells and whistles to the bustle of communication, but reflects something deep about how love is conceptualized.
Furthermore, this model provides a formal explanation for the morphogenetic role of the initial bell-shaped expression of the gene even-skipped, i.e. for the distinct effects of different levels of the Even-skipped protein on its target pair-rule genes.
Furthermore, the current analysis has revealed that genes that show the inverse bell-shaped expression pattern exist.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com