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Consideration of the dynamics of FNR switching in vivo showed that the dimeric variant, FNR D154A, was activated for gene expression at a rate comparable with that of wild-type FNR.
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Production or expression occurs at a rate that is modulated by feedbacks as shown in the diagram.
In the Smile condition, the participant was asked to alternate between a smiling and a neutral facial expression, at an alternation rate of about 1 s.
Because the present study focused on the exponential growth phase (i.e., gene expression at a constant growth rate), the unpredictable delay and/or time lags related to changes in both gene expression and growth could be neglected (Additional file 1: Figure S1).
RNA was isolated, and the microarray profiles were analyzed for differential gene expression at a 5% False Discovery Rate (FDR) [ 22].
In contrast, the expression of glycolysis pathway genes were initially repressed, followed by an initial peak expression at 0.3/hr growth rate and a second peak at the highest growth rate phase (0.7/hr).
This alteration of the dynamics makes the host gene ON-state (expression at maximum rate) robust with respect to a transient fading of the input activating signal, as the one depicted in Figure 3A.
The most plausible biological function of these repeats is that they promote phenotypic variation among otherwise clonal cells by altering protein expression profiles at a high rate [ 18].
Vrn1 expression occurs at a base rate of 0·08/HS in winter 'Batten' and 0·17/HS in spring 'Batten' during Phases 1, 3 and 4. Low temperatures promote expression of Vrn1 and accelerate progress toward VS.
This suggests that gene expression matures at a comparable rate in both regions.> -wrap-foot> In each panel, the number of differentially expressed genes are given for each comparison within the brain region indicated (A1 or MG).
To remove this biologically relevant variation component from the GAPDH and B2M expression, we identified a set of transcripts that correlated with the geometric mean of B2M and GAPDH expression at a 5% FDR (false-discovery rate).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com