Sentence examples for expression and turnover from inspiring English sources

Information on the target pharmacology, in particular its expression and turnover, drug-target binding kinetics, and knowledge of the fate of drug-target complexes, are generally required to build a mechanistic model.

The regulation of MS-KIF18A protein expression and turnover was explored by metabolic labeling and immunological analysis.

As the fiber cells mature, they lose the ability to maintain protein expression and turnover since the organelles are degraded.

We rather focussed on the effects of CGs on protein expression and turnover that we considered as more likely targets.

Previous studies by our laboratory have demonstrated that fucosylation regulates the expression and turnover of synapsin I, a protein involved in regulating neurotransmitter release and synaptogenesis (9).

In addition, differences in the expression and turnover of several components of the RISC pathways were observed among cell lines and tissues [ 27, 42].

RNase-controlled RNA degradation is a determining factor in the control of gene expression, maturation and turnover, which are further associated with the progression of cancers and infectious diseases.

Tau homeostasis is regulated by its expression, phosphorylation, and turnover.

Recent studies implicate that in addition to the tau protein expression level and turnover aberrant posttranslational modifications of tau protein such as phosphorylation [8], O-GlcNAc glycosylation [9] and oxidation [10] are involved in initiating tau aggregation.

In these cases, allometric scaling approaches may fail to accurately predict human drug exposure due to different target affinities, different target expression levels and turnover rates as they may not be proportional to body size.

Furthermore, we have shown for the first time regulation of MS-KIF18A mRNA expression and protein turnover by estrogen, implying the kinesins' function in estrogen-dependent manner.