Sentence examples for expression and therapy from inspiring English sources

Figure 1 a illustrates the overall process of in vitro preparation of GelMA/fGO hydrogel-based hybrid gene delivery system and its in vivo localized administration in the heart for prolonged gene expression and therapy.

We collected demographic information (age, menopausal status, and hospital of diagnosis), tumour characteristics (UICC stage, histological grade, and oestrogen-receptor expression), and therapy characteristics (primary surgical tumour management, receipt of radiation therapy, receipt of chemotherapy, and receipt of tamoxifen therapy) from the DBCG database.

Stage adjusted disease specific survival rate, according to MDR-1 expression and therapy in patients affected by RCC in early stage (stage I), has revealed that the group of patients with high MDR-1 expression and without adjuvant therapy showed poor survival (p < 0.05).

Notably, the different models all revealed a statistically significant correlation between defects in the p53 pathway (defined as L2/L3- TP53/ CHEK2 mutations or low level ATM expression) and therapy resistance defined as PD on treatment (P-values varying from 0.001 to 0.027; Figure 2B).

Loss of TP53-mediated control over ETS1 dependent transactivation of IKKα may represent a novel pathway for the constitutive activation of NF-κB mediated gene expression and therapy resistance in cancer cells [ 28] TP53 is therefore an ETS1 and ETS2 target gene [ 29].

In addition, association between miRNA expression, prognosis and therapy response prediction was repeatedly described9, 10.

Four clinical trials had recently not found a survival benefit of gastric cancers treated by standard chemotherapy plus anti-EGFR drugs [ 46- 49], and a retrospective EGFR analysis did not reveal significant associations between the immunohistochemical EGFR expression levels and therapy response or patient survival [ 48].

To elucidate the relationship between SMARCC1 expression and gemcitabine therapy, we used survival after recurrence, which represented the period from starting gemcitabine therapy or other therapies in 51 patients with relapse, until death.

These clinical studies illustrate the complexity regarding Bcl-2 expression and hormonal therapy resistance.

These drugs can induce apoptosis, alter gene expression, and reverse therapy resistance in preclinical models.

The potential interaction between protein expression and systemic therapy or primary tumour localisation was investigated using Cox regression.