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Importantly, several QGRS were detected in the vicinity of the intron-exon junctions of the SLC6A3: Because G-rich quadruplexes are actively involved in alternative and tissue-specific regulated splicing events [75], their positional effect on gene expression and the implication for DAT function could be most profound.
A relevant example is the well described presence of micrometastatic carcinoma cells in the blood and bone marrow that retain cytokeratin expression, and the implication of 'hybrid' cells in several systems.
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However, the intrinsic molecular mechanisms responsible for the functional association that exists between the experience of behaving aggressively, Th, Dat1, Snca and Bdnf expression and the implications of neurochemical events unfolding in the winners' brains have yet to be revealed.
Finally, in our Conclusion section, we describe the advance our study provides in the efforts to develop models of gene expression, and the implications of such work on understanding species response to climate change and on crop design.
However, a subtler question is how the architecture of a gene circuit influences the variability in gene expression, and what the implications are for population fitness.
Further work is underway by our research group to investigate the gene expression and the biological implications of the modulation of these genes, due to the displacement of zinc with cadmium as a function of their concentrations.
See the discussion section for further consideration of raw versus modeled gene expression data and the implications of variation in control gene expression under experimental treatments.
The main goal of the current work was to further study the role of ELOVL6 on these traits by analyzing the regulation of the expression of ELOVL6 and the implication of ELOVL6 polymorphisms on meat quality traits in pigs.
Our results show that, after BCR stimulation or BCR-TLR9 costimulation, the absence of Carabin in B cells accelerates Erk phosphorylation and increases Egr1 transcription and CD44 expression, confirming the implication of Erk phosphorylation in B-cell function as suggested by Dinkel et al (Dinkel et al, 1997; 1998).
Here we investigated the expression and clinical implication of C1orf63 in breast cancer.
However, the constraints on microRNA developmental expression and evolution, and the implications for animal evolution are less well understood.
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