Sentence examples for expression and stabilisation from inspiring English sources

Indeed, intratumoral ONYX-015 treatment induced significant expression and stabilisation of the p53 protein in the p53 wild-type IGRG121 tumour (Geoerger et al, 2002).

In breast cancer cells, IL1-beta increases the transcriptional activity of ER-alpha [ 19] which is a prognostic factor in breast cancer and the expression and stabilisation of IL-8 RNA [ 20] which is a potent angiogenic factor.

The pentose phosphate pathway (PPP) is up-regulated in cancer, and stabilisation of HIF1α increases expression of genes involved in the PPP (Riganti et al, 2012).

Interestingly, oncogenic KRAS is critical for maintaining high c-Myc levels in the HCT116/Hkh2 system (Shirasawa et al, 1993), and can promote expression of E2F1 (Berkovich and Ginsberg, 2001) and stabilisation of HIF1 α (Kikuchi et al, 2009).

We propose that BRCA1-deficient breast tumours, where abrogation of p53 function through mutation, appear to be a prerequisite for BRCA1-defective cancers to progress, would be extremely sensitive to 17-AAG treatment owing to the loss of S100A2 expression and thus increased HSP90-dependent stabilisation of mutant p53.

We have also shown that the exogenous expression of TIGAR mediated hypo-phosphorylation of RB protein and stabilisation of the RB E2F1 complex resulting in G1 arrest.

ALP is associated with the phase of differentiation and stabilisation of mineralised matrix [ 32]; OPG mRNA expression has been found to be increased during matrix production and maturation in rat calvaria cultures [ 33].

Therefore, the ability of S1P1 to enhance Mcl-1 expression may have an important role in the control of EC viability and stabilisation of mature vasculature by this receptor.

The very low mRNA levels of HSD1 and HSD2 strongly suggest a post-translational mechanism of protein stabilisation because high protein expression and metabolic activity of HSD1 have been previously reported in breast cancer tissue [ 31].

But he also combined growth and stabilisation policies in way that made them politically palatable.

Like CCTs, fiscal-responsibility laws and stabilisation funds have ricocheted around the region.