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Interestingly, no study has so far investigated in humans the relationship between plaque gene expression and released circulating factors, but analyzed in association with platelet aggregation in patients undergoing percutaneous intervention[ 8] that cause blood flux impairment and modulate the inflammatory response.
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They urged the Bahraini authorities to respect the rights to peaceful assembly and freedom of expression and release anyone arbitrarily detained for exercising legitimate freedoms without delay.
CRP is mainly expressed in hepatocytes; cytokines, especially interleukin-6, induce the expression and release of CRP [ 28, 29].
Analysis of cytokine expression and release after activation of TLR-4.
Hondares, E. et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
Increased cytokine expression and release have a cascade effect in HALI.
EPA and ALA increased FGF21 gene expression and release (Fig. 7h), but only EPA significantly increased cell temperature.
The expression and release of inflammatory cytokines IL-6 and granulocyte-macrophage colony-stimulating factor were increased after rhWNT3A exposure of HNEpCs.
As expected, AH7614 significantly inhibited the capacity of GW9508 to induce FGF21 expression and release in brown and beige adipocytes (Fig. 8g).
AH7614 also inhibited the effects of EPA on FGF21 expression and release, indicating that these effects involve GPR120 in brown and beige adipocytes.
Next, we used two independent approaches to determine whether EPA affects FGF21 expression and release by previously differentiated brown or beige adipocytes, and whether GPR120 mediated these effects.
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