CRP is mainly expressed in hepatocytes; cytokines, especially interleukin-6, induce the expression and release of CRP [ 28, 29].
Analysis of cytokine expression and release after activation of TLR-4.
Hondares, E. et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
EPA and ALA increased FGF21 gene expression and release (Fig. 7h), but only EPA significantly increased cell temperature.
Increased cytokine expression and release have a cascade effect in HALI.
The expression and release of inflammatory cytokines IL-6 and granulocyte-macrophage colony-stimulating factor were increased after rhWNT3A exposure of HNEpCs.
Next, we used two independent approaches to determine whether EPA affects FGF21 expression and release by previously differentiated brown or beige adipocytes, and whether GPR120 mediated these effects.
As expected, AH7614 significantly inhibited the capacity of GW9508 to induce FGF21 expression and release in brown and beige adipocytes (Fig. 8g).
AH7614 also inhibited the effects of EPA on FGF21 expression and release, indicating that these effects involve GPR120 in brown and beige adipocytes.
There are significant differences in the type and temporal sequence of cytokine expression and release in the adult and newborn lung in response to hyperoxia.
Our study also shows that some of the effects triggered by GPR120 activation are mediated via the GPR120-induced expression and release of FGF21 in brown and beige adipose tissues.
