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Exact(14)
However, the exact pathophysiology remains unclear, and different underlying mechanisms have been proposed, including protein expression and modification as well as protein-protein interactions.
Protein expression and modification were analyzed by immunoblot.
The expression and modification of miRNAs have been an area of intense interest.
A method that permitted this to be done simultaneously would be convenient and would provide information on both protein expression and modification.
In contrast to mRNA-based approaches, for which mRNA levels do not always parallel protein levels, proteomics is a definite tool for detecting changes in protein expression and modification.
The signal mediators, Chk1 and Chk2, reveal a similar pattern of expression and modification.
Similar(46)
This could explain in part the alteration of certain gene expression and modifications of the cell metabolism in patients with long-term HIV-1 infection.
Mechanisms of susceptibility may also be dependent on non-transcriptional events such as protein expression and modifications, as well as polymorphisms in specific genes and proteins, which lie beyond the scope of the current study.
These contain diverse cellular components and co-factors that enhance protein expression, folding and modification in different ways.
This study aims to characterize cellular senescence at the level of global protein expression profiles and modification of proteins with O-linked N-acetylglucosamine (O-GlcNAcylation).
Using the Illumina high-throughput sequencing data of the mRNA transcriptome, DNA methylome and H3K27me3 modification in hybrid maize seedling tissue, we developed a computational procedure for detecting allele-specific gene expression and epigenetic modification.
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