Sentence examples for expression and attenuation from inspiring English sources

Bi, G. et al. Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown.

We provide here novel evidence that N-cadherin acts as a negative regulator of cell proliferation and survival in osteoblasts via interaction with LRP5, alteration of autocrine Wnt3a ligand expression and attenuation of Wnt, ERK and PI3K/Akt signalling pathways.

Overall, our results indicate that N-cadherin controls cell proliferation and survival in osteoblasts by mechanisms involving alteration of autocrine/paracrine Wnt3a ligand expression and attenuation of Wnt, ERK and PI3K/Akt signalling pathways (Figure 8D).

The data show that N-cadherin negatively controls osteoblast proliferation and survival via inhibition of autocrine/paracrine Wnt3a ligand expression and attenuation of Wnt, ERK and PI3K/Akt signalling, which provides novel mechanisms by which N-cadherin regulates osteoblast number.

For instance, reduction in BMAL1 protein expression and attenuation of its circadian rhythm in aged articular cartilage could lead to increased cell senescence.

However, when forskolin was used in conjunction with PMA, a doubling of CD86 expression and an attenuation of CD11b up-regulation was observed.

Due to the crucial role of c-Src in NF-κB activation during hypoxia [5], the block of c-Src activation emerges as a novel mechanism whereby GD3 inactivates NF-κB, although a direct effect on DNA-competent κB members by GD3 shown previously [11], [16] could contribute to the final outcome of impaired κB-mediated gene expression and subsequent attenuation of survival pathways (Figure 5).

As demonstrated in a different study, it increases the promoter affinity for the stimulatory protein (Sp) 1, intensifying MDM2 expression, and subsequent attenuation of the p53 pathway [ 20].

Aside from the alterations in BBB transporter expression, and the attenuation of CSF bulk flow, enzymatic degradation of Aβ by insulin-degrading enzyme and/or neprilysin may also be diminished [ 32].

IFN-γ is also able to switch the balance of IL-10 STAT activation from STAT3 to STAT1, with concomitant downregulation of STAT3-dependent gene expression, and partial attenuation of IL-10 anti-inflammatory function [ 86].

Inflammation appears to increase expression of FcγRIIa, and attenuation of inflammation decreases expression of FcγRIIa (25).