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Multivariate Cox regression was used to investigate the prognostic power of candidate gene expression adjusting for established prognostic variables.
We then applied multivariable Cox regression model with MRP1 and MRP4 expression adjusting for all known clinical and pathological prognostic factors.
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Statistically significant changes in gene expression (adjusted p < 0.05) were determined using ANOVA.
- P-value associated to the statistical analysis for differential expression adjusted for multiple comparisons.
Results are reported for one polymorphisms stratified by the other polymorphisms or p53 expression, adjusted for other covariates.
Abundant kif21b expression adjusted for the percentage of GM demyelination revealed that a rapid progression to EDSS 6.0 is independent of the percentage of GM demyelination.
The best model for S results included three SNPs that accounted for a very large fraction of variability in IRF5 expression (adjusted r2 = 0.80).
In sum, fasting altered the expression (adjusted p values ≤ 0.05) of 107 proteins in liver samples and 35 proteins in muscle samples (Tables S 8 and S 9).
Linear modeling and tests for differential expression, adjusted for multiple testing, were performed in the Linear Models for Microarray Analysis (LIMMA) [ 36] software package.
Their expression level showed some fluctuations in the regenerating tissues, but not above the cut-off threshold (twofold change in expression, adjusted p-value < 0.001), with the exception of up-regulated Sox11, Bmp7 and down-regulated Prom1, Isl1, and Lhx3.
These files contain mappings from Entrez Gene IDs (first column) to expression values (log2 fold changes listed in the second column) and a statistic estimating the probability of differential expression (adjusted p-values listed in the third column).
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