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Nominalized verb formations such as verbal nouns, participles, and predicative adjectives probably harken back to the protolanguage and can be reconstructed for predicates expressing state rather than action.
Equations expressing state and transition probabilities are subsequently given, providing a formal model for evaluating the MIN's performance.
Gene ontology analysis of targets which are uniquely bound by MYCN in the over expressing state revealed enrichment for DNA helicases and mRNA transcriptional regulation, amongst others.
In our data, DVL2, DVL3, APC and TCF7 were identified as bound by MYCN only in the over expressing state (Kelly and SHEP untreated).
KEGG pathway analysis revealed a shortlist of genes whose promoters uniquely bound MYCN in the over expressing state and who are members of established signalling pathways which are dysregulated in cancer.
Following the removal of L5 (ΔL5), cultures derived from colonies expressing ade6 + retained the expressing state in 100% of cells.
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We choose the Event-B modeling language for expressing state-based models and we show how we can play Event-B scores using Rodin and methodological elements to guarantee that the resulting algorithm is correct with respect to initial requirements.
Then: Corollary Define the events hls1 on as when the gene HLS1 is in its expressed state due to the expression of the ERF1 gene and arf2 on as when the gene ARF2 is in its expressed state.
We can express this statement as a mathematical proposition: Define the events hls1 on as when the gene HLS1 is in its expressed state due to the expression of the ERF1 gene, and erf1 on as when the master gene ERF1 is in its expressed state, i.e. hls1 on ⊂ erf1 on.
The only difference is that the expressed state is non-representational.
This model might account for cellular heterogeneity, if the duration of the silent or expressed state is itself a stochastic feature, akin to a half-life.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com