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62 The critical importance of these differences was illustrated by the clinical Phase I/II study of an AAV2-based vector expressing factor IX.
Amongst several strategies that promote complement evasion, N. meningitidis recruits the human negative complement regulator, complement factor H CFHH), to its surface by expressing factor H binding protein (fHbp) (Schneider et al., 2006, 2009; Madico et al., 2007).
Here we show that liver gene therapy by lentiviral vectors (LVs) expressing factor IX (FIX) strongly reduces pre-existing anti-FIX antibodies and eradicates FIX inhibitors in haemophilia B mice.
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Research has shown that tumors can facilitate their growth by expressing factors that co-opt and suppress immune-surveillance mechanisms.
Stromal cells play a pivotal role in normal, physiological inflammation and persistent inflammatory disease by expressing factors such as cytokines and chemokines that define local immune responses.
GRPR (gastrin-releasing peptide receptor) is a highly expressed factor in pancreas and assists insulin secretion by stimulating the autonomic nerves (Figure 5C [76].
And, Oct-1 has been demonstrated as a ubiquitously expressed factor [52].
The LSP has been used previously to express Factor IX from the liver of mice [57].
The methylation status of specific conserved sequences regulates the binding of the ubiquitously expressed factor CTCF to the ICR, which functions as an insulator and enhancer blocker.
We observed that CTGF was an expressed factor of cytoplasm in NPC and noncancerous NP tissues.
An analysis of a series of serous ovarian carcinoma samples (n=25) demonstrated that all tumours expressed factor H/FHL-1.
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