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In the endogenous GLI3 expressing environment (H661) they functioned as activators whilst in the GLI3 negative (H441) cellular context they actively repressed the transcription (Figure 2).
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In the present study, many major QTLs expressing across environments were identified.
From a finalistic point of view, this could be interpreted as an adaptation of NK cells to the low HLA class I-expressing environment in which they develop, as a higher expression level of broad-spectrum IR might be able to still transmit enough inhibitory signals to the NK cells and thus contribute to self-tolerance.
The applicability of the model is illustrated by using a case study along with a sensitivity analysis on financial parameters expressing the business environment.
Early TB lesions were characterized by a highly pro-inflammatory environment, expressing high levels of immune signaling pathways involving IFNγ, TNFα, JAK, STAT and C-C/C-X-C chemokines.
Of these groups, 4 LEAF groups and 4 STEM groups were stably expressed across environments.
Effective utilization of favorable QTL alleles in crop breeding requires QTL to be stably expressed across environments and years.
QTL that are consistently expressed among environments are favorable targets for marker-assisted selection in the development of widely distributed agricultural varieties [ 9].
In particular, many more transcripts of Cytochrome c oxydase were differentially expressed between environments in GRB vs. MR (17 vs. 3).
The majority of QTL mapped in our study was stably expressed over environments and detected with coincident or overlapping 1-LOD support intervals over multiple years and/or locations.
In our study, the majority of QTL we discovered were stably expressed over environments and were detected at the same or very similar map position over multiple years and/or locations.
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