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Another SC population of the UI region expresses low levels of α6-integrin and lacks CD34 and Sca-1 expression (Jensen et al, 2008).
Conversely, a human myeloid leukemia line that normally expresses low levels of CD47 was able to cause leukemia in mice only after Jaiswal engineered it to express higher levels of the molecule.
Using the B16 melanoma, a poorly immunogenic experimental tumor that expresses low levels of MHC class I products, we investigated whether DCs loaded ex vivo with apoptotic tumor cells could elicit combined CD4 and CD8 T cell dependent, long term immunity following injection into mice.
Uptake of 111In-bevacizumab was low in xenografts derived from MDA-MB231 IE3 (2.1 ± 0.3%ID/g), which expresses low levels of VEGF (Fig. 3a).
In order to better understand the function of phospholamban in living systems, a transgenic mouse model was established employing targeted overexpression of phospholamban to the atrium, which normally expresses low levels of the protein.
The liver expresses low levels of Fas constitutively which increase rapidly during inflammation rendering hepatocytes potentially susceptible to Fas-mediated death.
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Lrig1-expressing cells in the upper part of the follicle expressed low levels of β1 integrins.
By contrast, senescent cells expressed low levels of NF90, thus allowing SASP factor expression to increase.
Interestingly, cDCs from the DLE patients expressed low levels of the inhibitory molecule PD-L1 and showed a high expression of CCR6, which correlated with disease activity.
Pericyte-2 cells expressed Agtr1a, Vsnl1, and Art3, but lacked or expressed low levels of Acta2.
In cells expressing low levels of GP2-Cad1, protein levels and stoichiometry of the endogenous cadherin-catenin complex were unaffected.
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