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A high level of inbreeding results in increased homozygosity and expression of deleterious recessive alleles not expressed to the same extent in large natural populations.
Notably, although expressed to the same level, the Jak2 binding mutant Jak2(Y119E) had little effect on the steady state of GHR.
If all recessive alleles in the population are phenotypically expressed to the same degree independently of environmental conditions (i.e. unconditional alleles), no inbreeding by environment interaction would be observed.
Expression levels do not appear to be associated with the size of the DXZ4 allele indicating that not all monomers within an array are expressed to the same extent.
The expression of wild-type Zfp277 extended the replicative life span of Zfp277−/− MEFs, whereas the expression of Zfp277141 458 did not (Figure 7C), despite that the mutant Zfp277 protein was expressed to the same levels of wild-type Zfp277 and retained a nuclear localization (data not shown).
When individual integrations into the genome are used for each of the subunits, genes that are part of the same pathway may not be expressed to the same level or even in the same cell, even when expressed from identical promoters.
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Pathogenic and non-pathogenic mutations of PrP over-expressed to the same extent as PrPC alter cellular LIP and ferritin iron content differentially, specific to the mutation.
Unlike GGPS, no other consensus gene was over-expressed to the same magnitude (<10-fold) in neem when compared to the other three species studied.
Polycistronic miRNAs are highly likely to be expressed at the same time and location, and therefore to be functionally related.
Neighboring gene pairs in the genome of Saccharomyces cerevisiae have a tendency to be expressed at the same time.
As shown in Figure 2B, immunoblotting confirmed that the T51A mutant is indeed expressed and to the same extent as the WT PAGE4.
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