Here, we comparatively analyzed wt and ADAM8−/− mice to identify in more detail the thymic cell subsets that express ADAM8 and to identify a potential function for ADAM8 in T cell development.
Correlation analysis, a method selecting genes that are correlated with a single differentially expressed gene, was used to identify a biomarker set in a Gambian cohort [ 5].
Then, we applied our weighted t-cover hitting set algorithm to each bipartite component induced by connecting the differentially expressed genes and TFs to identify a set of cooperative TFs from the component.
As most lncRNAs have no poly(A) tails and are lowly and specifically expressed [ 4, 16], to identify a comprehensive set of lncRNAs including non-poly(A -tailed lncRNA -tailedtruncatulncRNAsconducted genome-wine high-throughput sequencing of six libraries prepared using coM.lementruncatulances of synthetic adaptors.
The large numbers of mice used in the study, and the variety of different mouse models provided greater sensitivity and statistical confidence in selection of differentially expressed genes allowed us to identify a comprehensive list of genes, PRGs, from our BMAP microarrays that are consistently deregulated in these models.
Finally, the researchers mined a comprehensive atlas of genes expressed in the mouse brain to identify a cell surface receptor, called Npy1, which is expressed exclusively in dentate gyrus granule cells, and found that activating this receptor in normal mice with a synthetic peptide that selectively binds to it caused the same learning-induced memory loss seen in the other experiments.
For both overall and prostate expressed genes, we have failed to identify a significant difference in the transcriptomes between rat and human prostate cancer cell lines.
After assembling a database of expressed sequence tags--short DNA sequences that can be used to identify a gene expressed in a cell at a given time--Reppert and his colleagues located two families of cryptochromes in the monarch.
These efforts have resulted in a wealth of publicly available RNA expression data used to identify differentially expressed transcripts, which can be used to identify a CRC-specific signature.
Surprisingly, the array data showed high similarity between the NP and the AF transcriptome and failed to identify a differentially expressed transmembrane-containing domain gene between both tissues.
